Kinase Sensing Based on Protein Interactions at the Catalytic Site

Invited for the cover of this issue is Assaf Friedler, Shlomo Yitzchaik and co‐workers at the Hebrew University of Jerusalem and the Academia Sinica. The image depicts a new approach for electrochemical kinase sensing that does not rely on phosphorylation. The kinase binds a peptide layer, which und...

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Published inChemistry : a European journal Vol. 28; no. 17; pp. e202200655 - n/a
Main Authors Solomon, Ohad, Sapir, Hannah, Mervinetsky, Evgeniy, Chen, Yu‐Ju, Friedler, Assaf, Yitzchaik, Shlomo
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 22.03.2022
Subjects
Catalytic Domain
Chemistry
Electrochemistry
Humans
Kinases
Peptides
Phosphorylation
Protein interaction
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Summary:Invited for the cover of this issue is Assaf Friedler, Shlomo Yitzchaik and co‐workers at the Hebrew University of Jerusalem and the Academia Sinica. The image depicts a new approach for electrochemical kinase sensing that does not rely on phosphorylation. The kinase binds a peptide layer, which undergoes rearrangement, resulting in the permeation of redox‐active species through the layer and electrochemical sensing. Read the full text of the article at 10.1002/chem.202104227. “… we developed a new approach for electrochemical kinase biosensing that does not rely on enzymatic phosphorylation detection…” This and more about the story behind the front cover can be found in the article at 10.1002/chem.202104227).
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ISSN:0947-6539
1521-3765
1521-3765
DOI:10.1002/chem.202200655