Antidiarrheal, anti‐inflammatory and antioxidant effects of Anethum graveolens L. fruit extract on castor oil‐induced diarrhea in rats

• Published in: Neurogastroenterology and motility Vol. 36; no. 11; pp. e14892 - n/a
• Main Authors: Brinsi, Chirine, Jedidi, Saber, Sammari, Houcem, Selmi, Houcine, Sebai, Hichem
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.11.2024
• Subjects: Alkaline phosphatase; Anethum gravelons L; Antioxidants; Castor oil; Diarrhea; Flavonoids; Fruits; Hydrogen peroxide; inflammation; Intoxication; nutraceutical; Oils & fats; oxidative stress; Phenolic compounds; Polyphenols; Prophylaxis; Anethum gravelons L; Castor oil; inflammation; diarrhea; oxidative stress; nutraceutical
• ISSN: 1350-1925; 1365-2982; 1365-2982
• DOI: 10.1111/nmo.14892

Background Between food and medicine, nutraceuticals are widely used in human health for the prevention and treatment of various diseases. This study aims to determine the cytoprotective effects of Anethum gravelons fruit extract (AGFAE) on castor oil‐induced diarrhea in rats due to its phytochemical and antioxidant properties. Methods Male rats were divided into six groups of six animals each: Control (C), Castor oil (CO), CO + different doses of AGFAE (50, 100, and 200 mg/kg, b.w., p.o.), and the CO + loperamide group (LOP, 10 mg/kg, b.w., p.o.). Key Results In vitro, the chemical composition of aqueous Dill fruit extract showed strong antioxidant activity, with a high content of total polyphenols, flavonoids, and tannins. In our in vivo studies, pre‐treatment with AGFAE reduced malondialdehyde and hydrogen peroxide levels and maintained normal activity of enzymatic and non‐enzymatic antioxidants in the gastric and intestinal mucosa. In addition, we found that AGFAE prophylaxis improved the stability of many plasma biochemical parameters altered by castor oil intoxication, such as C‐reactive protein concentrations and alkaline phosphatase activities. Conclusions & Inferences We suggest that AGFAE phenolic compounds had significant protection against diarrhea involving several mechanisms such as reducing hypersecretion, peristaltic, inflammation, and preserving the endogenous antioxidant levels. In this graphical we demonstrated the antidiarrheal, anti‐inflammatory and antioxidant actions of Anethum graveolens L. fruit extract induced with castor oil in rats. The AGFAE may be an effective treatment for inhibiting intestinal transit in diarrheal disorders such as that induced by castor oil. This makes the protective pre‐treatment of gastrointestinal pathology by nutritherapy more effective than allopathy.