The association between proton‐pump inhibitor use and recurrence of hepatocellular carcinoma after hepatectomy
Background and Aim The association between long‐term proton‐pump inhibitors (PPIs) use and malignancies had long been discussed, but it still lacks consensus. Our study investigated the association between PPI use and hepatocellular carcinoma (HCC) recurrence following curative surgery. Methods We r...
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Published in | Journal of gastroenterology and hepatology Vol. 39; no. 10; pp. 2077 - 2087 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Australia
Wiley Subscription Services, Inc
01.10.2024
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Subjects | |
Online Access | Get full text |
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Summary: | Background and Aim
The association between long‐term proton‐pump inhibitors (PPIs) use and malignancies had long been discussed, but it still lacks consensus. Our study investigated the association between PPI use and hepatocellular carcinoma (HCC) recurrence following curative surgery.
Methods
We retrospectively enrolled 6037 patients with HCC who underwent hepatectomy. Patients were divided into four groups according to their PPI usage. (non‐users: < 28 cumulative defined daily dose [cDDD]; short‐term users: 28–89 cDDD; mid‐term users: 90–179 cDDD, and long‐term users: ≥ 180 cDDD, respectively). Recurrence‐free survival (RFS) and overall survival (OS) were analyzed using Kaplan–Meier method and Cox proportional hazard models.
Results
Among the 6037 HCC patients, 2043 (33.84%) were PPI users. PPI users demonstrated better median RFS (3.10 years, interquartile range [IQR] 1.49–5.01) compared with non‐users (2.73 years, IQR 1.20–4.74; with an adjusted hazard ratio [aHR] of 0.57, 95% confidence interval [CI] 0.44–0.74, P < 0.001). When considering the cumulative dosage of PPI, only long‐term PPI users had significant lower risk of HCC recurrence than non‐PPI group (adj‐HR: 0.50; 95% CI: 0.35–0.70; P < 0.001). Moreover, the impact of long‐term PPIs use on improving RFS was significant in most of the subgroup analysis, except in patients with advanced tumor stages, with non‐cirrhosis, or with a history of chronic kidney disease. However, there were no significant differences in median OS between PPI users and non‐users (4.23 years, IQR 2.73–5.86 vs 4.04 years, IQR 2.51–5.82, P = 0.369).
Conclusion
Long‐term PPI use (≥ 180 cDDD) may be associated with a better RFS in HCC patients after hepatectomy. |
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Bibliography: | Chia‐Chu Fu contributed to data collecting and interpreting, and manuscript drafting. Chun‐Ting Ho contributed to data collection and interpretation, and manuscript drafting. Elise Chia‐Hui Tan contributed to study planning and data interpretation. Wei‐Yu Kao contributed to study planning and data interpretation. Pei‐Chang Lee contributed to data collection. Yi‐Hsiang Huang, Teh‐Ia Huo, Ming‐Chih Hou, and Jaw‐Ching Wu contributed to study planning. Chien‐Wei Su contributed to conducting, data interpretation, and manuscript drafting. All authors approved the final version of the article, including the authorship list. There are no potential conflicts of financial and non‐financial interests in the study. Chien‐Wei Su: Speakers' bureau: Gilead Sciences, Bristol‐Myers Squibb, AbbVie, Bayer, and Roche. Advisory arrangements: Gilead Sciences. Grants: Bristol‐Myers Squibb, and Eiger. Declaration of conflict of interest Author contributions ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0815-9319 1440-1746 1440-1746 |
DOI: | 10.1111/jgh.16640 |