Bacterial vaginosis: culture- and PCR-based characterizations of a complex polymicrobial disease's pathobiology

Bacterial vaginosis (BV) is an enigmatic polymicrobial disease, and its evolution and pathobiology will not be solved by traditional culture-based methods. Characterization of the vaginal microbiota by polymerase chain reaction-based methods holds great promise. Molecular studies have identified spe...

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Bibliographic Details
Published inCurrent infectious disease reports Vol. 9; no. 6; pp. 485 - 500
Main Authors Kalra, Apoorv, Palcu, Cristina T, Sobel, Jack D, Akins, R A
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.11.2007
Subjects
Bacteria
Disease
Gynecology
Infectious diseases
Pathology
Polymerase chain reaction
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Summary:Bacterial vaginosis (BV) is an enigmatic polymicrobial disease, and its evolution and pathobiology will not be solved by traditional culture-based methods. Characterization of the vaginal microbiota by polymerase chain reaction-based methods holds great promise. Molecular studies have identified species not detected by culture, but they also have missed some species identified by culture. These studies allow classification of both normal and BV patients based on distinct microbiologic profiles, which may prove important in accessing risk of BV, response to treatment, and risk of complications. More studies using new generations of primers and standardized methods are needed, and data must be analyzed after grouping patients according to microbiologic profiles.
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ISSN:1523-3847
1534-3146
DOI:10.1007/s11908-007-0074-4