Antifungal activity and hair growth stimulation of purple sweet potato leaf fraction (Ipomoea batatas (L.) Lamk) and its molecular mechanism through androgen receptor inhibition
Alopecia presented a global challenge, spurring the search for new treatments. This study evaluated Ipomoea batatas leaf extracts for their ability to stimulate hair growth and inhibit Malassezia furfur . Secondary metabolites were identified and assessed for their potential to inhibit androgen rece...
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Published in | Farmacija Vol. 71; pp. 1 - 14 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Pensoft Publishers
29.05.2024
|
Online Access | Get full text |
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Summary: | Alopecia presented a global challenge, spurring the search for new treatments. This study evaluated
Ipomoea batatas
leaf extracts for their ability to stimulate hair growth and inhibit
Malassezia furfur
. Secondary metabolites were identified and assessed for their potential to inhibit androgen receptors (AR) via LC-MS/MS and
in silico
analysis. The hair tonic formulation was optimized using a D-optimal mixture design to improve physicochemical properties. The plant’s extracts and fractions exhibited strong antifungal activity against
M. furfur
and significant hair growth stimulation compared to minoxidil.
In silico
analysis identified pyropheophorbide A, methyl-Pyropheophorbide A, hyperoside, and quercetin with superior affinity and stability in interacting with AR. The optimized formulation included 96% ethanol, propylene glycol, and Tween 80 to enhance hair tonic properties.
I. batatas
leaves showed promising potential in treating alopecia through hair growth stimulation, antifungal activity, and potential inhibition of AR. These findings opened avenues for further research and development in alopecia therapeutics. |
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ISSN: | 0428-0296 2603-557X |
DOI: | 10.3897/pharmacia.71.e119384 |