Signal Passageway of Phenolic Acid in Opposition to Malignancy Management

• Published in: Current pharmacology reports Vol. 9; no. 4; pp. 247 - 259
• Main Authors: Sandhiya, V., Senthilkumaran, K., Ubaidulla, U
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.08.2023
• Subjects: Biomedical and Life Sciences; Biomedicine; Cancer Research; Immunotherapy in Cancer Research; Molecular Medicine; Nanotechnology; Nutraceuticals; Pharmacology/Toxicology; Topical Collection on Naturopathy; Polyphenols; Herbal medicines; Anticancer agent
• ISSN: 2198-641X; 2198-641X
• DOI: 10.1007/s40495-023-00321-3

Background One of the main causes of concern for the worldwide public health system is cancer, which is a diverse disease. Here, the abundance of different chemicals and pharmacologically active substances found in nature serves as a source for anticancer medications. Some natural compounds and their synthetic analogues have been studied in the last 10 years as potential cancer treatments. Polyphenols are secondary metabolites of plants that are amongst the enormous phytochemicals engaged in the defence against many types of stress. Body Polyphenols have demonstrated potential health advantages in a number of oxidative stress–related disorders, including cancer, as a result of their powerful antioxidant effects. Polyphenols have the ability to stop the growth, spread, and carcinogenesis of tumour cells. The development of successful anticancer medicines depends on a thorough understanding of tumour biology, the discovery of novel molecular targets, the creation of specialised antitumour agents, and increasing the susceptibility of tumour cells to standard/targeted therapy. The use of natural compounds, particularly polyphenols, as a source of anticancer medications is the main topic of this review paper. This briefly describes the molecular mechanisms that affect various cancer cell types.