A case of advanced hepatocellular carcinoma showing marked tumor necrosis after administration of CDDP powder for intraarterial use

• Published in: Kanzo Vol. 48; no. 1; pp. 27 - 32
• Main Authors: Ishikawa, Toru, Kamimura, Hiroteru, Tsuchiya, Atsunori, Watanabe, Kouji, Seki, Keiichi, Ohta, Hironobu, Yoshida, Toshiaki, Tsubono, Toshihiro, Takeda, Keiko, Ishihara, Noriko, Kamimura, Tomoteru
• Format: Journal Article
• Language: Japanese
• Published: The Japan Society of Hepatology 2007
• Subjects: CDDP; hepatocellular carcinoma; intra-arterial infusion chemotherapy
• ISSN: 0451-4203; 1881-3593
• DOI: 10.2957/kanzo.48.27

A 61-year old Japanese woman positive for anti-HCV was referred to our hospital because of liver tumor and high levels of α-fetoprotein and protein induced by Vitamin K absence or antagosist II. After examinations, she was diagnosed as having advanced hepatocellular carcinoma. She was treated with hepatic arterial cisplatin infusion chemotherapy for hepatocellular carcinoma. Subsequently, she underwent partial liver resection. Specimens of resected tumor were hepatocellular carcinoma with marked necrosis. Vivid tumor tissue was detected only in subcapsular portion of the tumor. We suppose that arterial cisplatin infusion chemotherapy may have contributed to high antineoplatic effect of hepatocellular carcinoma.