Lipopigment Changes in Purkinje Cells in Alzheimer's Disease
Cerebellar tissue was examined from 22 patients with Alzheimer's disease (AD) and from an age-matched group of 20 non-diseased subjects. Intraneuronal lipopigment in the bodies of 1344 Purkinje cells (PCs) (32 per brain) was identified by fluorescence microscopy. The mean total area (per PC) of...
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Published in | Journal of Alzheimer's disease Vol. 1; no. 2; pp. 71 - 79 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
London, England
SAGE Publications
01.12.1998
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Subjects | |
Online Access | Get full text |
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Summary: | Cerebellar tissue was examined from 22 patients with Alzheimer's disease (AD) and from an
age-matched group of 20 non-diseased subjects. Intraneuronal lipopigment in the bodies of
1344 Purkinje cells (PCs) (32 per brain) was identified by fluorescence microscopy. The
mean total area (per PC) of the outlines of discrete regions of lipopigment in a PC
perikaryon for the AD-related group of PCs was significantly greater than the mean for the
comparison group (p < 0.001). Also, the two groups of PCs showed significant
(< 0.05) differences in the mean number (per PC) of discrete regions of lipopigment in
11 size categories. The findings indicate a lysosomal abnormality in PCs in AD. The
pattern of size distribution of lipopigment in PCs differed from that previously-reported
for neurons of the frontal cortex. These differences may be associated with the absence of
senile plaques and the presence of “diffuse” amyloid plaques in the cerebellum in AD |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1387-2877 1875-8908 |
DOI: | 10.3233/JAD-1998-1201 |