In-situ synthesis and evaluation of anti-bacterial efficacy and angiogenesis of curcumin encapsulated lipogel dermal patch for wound healing applications

• Published in: Biomaterials advances Vol. 164; p. 213989
• Main Authors: Poornima, Govindaraj, Deepa, Murugan, Devadharshini, Mohan, Gopan, Gopika, Mani, Maheswaran, Kannan, S
• Format: Journal Article
• Language: English
• Published: Netherlands 01.11.2024
• Subjects: Drug release; Angiogenesis; Curcumin; Antibacterial; Liposomes
• ISSN: 2772-9508; 2772-9508
• DOI: 10.1016/j.bioadv.2024.213989

The development of synthetic hydrogels as a dermal patch offers unique advantage of providing moist environment around the wound site. The incorporation of curcumin in hydrogel plays a significant role in the healing process of chronic wounds. The present investigation aims to develop nano-formulated curcumin-fused lipogel to impart the dual advantages of sustained drug release and enhanced wound healing ability. The wound healing behaviour of the prepared lipogel has been assessed through series of techniques namely DPPH assay and bacterial inhibitory efficacy through the Kirby Bauer assay against E. coli and S. aureus. Further, the promotion of angiogenesis has been determined through an in-ovo CAM assay. The results obtained from the investigation revealed the enhanced solubility of curcumin in liposome formulation. Moreover, the encapsulation of curcumin in liposomes facilitated prolonged drug release and better antibacterial efficacy against the tested bacterial stains. The developed hydrogel also displayed good adhesion and water retention ability, which is an important prerequisite for better wound healing ability.