Optogenetic modulation of cardiac autonomic nervous system

The following is a narrative review of the fundamentals of optogenetics. It focuses on the advantages and constraints of manipulating the autonomic nervous system by modifying the pathophysiological characteristics that arise in different diseases. Although the use of this technique is currently exp...

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Published inAutonomic neuroscience Vol. 255; p. 103199
Main Authors Hernández-Domínguez, Ramon A., Herrera-Orozco, Jorge F., Salazar-Calderón, Guadalupe E., Chávez-Canales, María, Márquez, Manlio F., González-Álvarez, Felipe, Totomoch-Serra, Armando, Reyes-Cruz, Tania, Lip, Finn, Aceves-Buendía, José J.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.10.2024
Subjects
Arrhythmias
Autonomic nervous system
Optogenetics
Parasympathetic
Sympathetic
Parasympathetic
RVLM
ANS
IML
HR
Optogenetics
CVLM
TRPV1
NTS
Sympathetic
vGluT2
DMNV
NA
Autonomic nervous system
ChAT
Arrhythmias
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Summary:The following is a narrative review of the fundamentals of optogenetics. It focuses on the advantages and constraints of manipulating the autonomic nervous system by modifying the pathophysiological characteristics that arise in different diseases. Although the use of this technique is currently experimental, we will discuss improvements that have been implemented and identify the necessary measures for potential preclinical translation in the control of the cardiac autonomic nervous system.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-3
content type line 23
ISSN:1566-0702
1872-7484
1872-7484
DOI:10.1016/j.autneu.2024.103199