Role of the mechanisms of replicative cellular senescence in structural and functional changes of the vascular wall in chronic kidney disease

This review considers the mechanisms and risk factors for the development of replicative cellular senescence of the vascular wall in patients with CKD and discusses therapeutic approaches to slowing the accelerated vascular aging.

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Bibliographic Details
Published inTerapevtic̆eskii arhiv Vol. 89; no. 6; p. 102
Main Authors Rudenko, T E, Bobkova, I N, Kamyshova, E S, Gorelova, I A
Format Journal Article
LanguageRussian
Published Russia (Federation) 2017
Subjects
Cellular Senescence
Humans
Renal Insufficiency, Chronic - pathology
Renal Insufficiency, Chronic - physiopathology
chronic kidney disease
telomerase
cardiovascular risk
telomeres
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Summary:This review considers the mechanisms and risk factors for the development of replicative cellular senescence of the vascular wall in patients with CKD and discusses therapeutic approaches to slowing the accelerated vascular aging.
ISSN:0040-3660
DOI:10.17116/terarkh2017896102-109