MBL2 gene polymorphisms related to HIV-1 infection susceptibility and treatment response

Human Mannose-binding lectin (MBL) is a protein encoded by MBL2 gene involved in the activation of the lectin-complement pathway. Several studies emphasized the role of MBL2 gene in several infectious diseases’ susceptibility, including HIV-1 infection. We aim to investigate the impact of 10 MBL2 ge...

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Bibliographic Details
Published inHuman immunology Vol. 84; no. 2; pp. 80 - 88
Main Authors Bouqdayr, Meryem, Baba, Hanâ, Saih, Asmae, Abbad, Anass, Hamdi, Salsabil, Marih, Latifa, Sodqi, Mustapha, Ouladlahsen, Ahd, Marhoum El Filali, Kamal, Moussamih, Samya, Saile, Rachid, Kettani, Anass, Wakrim, Lahcen
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.02.2023
Subjects
Disease development
Genetic Predisposition to Disease
Genotype
Haplotypes
HIV Infections - genetics
HIV Seropositivity
HIV-1
Humans
Infection susceptibility
Mannose-Binding Lectin - genetics
MBL2 gene
Polymorphism, Genetic
Polymorphisms
HIV-1
Disease development
ART
OR
CDC
MBL/MBP
CI
AIDS
PRM
χ2
Polymorphisms
EDTA
CD4
UTR
Infection susceptibility
CRD
DNA
MBL2 gene
SNPs
MASPs
PCR
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Summary:Human Mannose-binding lectin (MBL) is a protein encoded by MBL2 gene involved in the activation of the lectin-complement pathway. Several studies emphasized the role of MBL2 gene in several infectious diseases’ susceptibility, including HIV-1 infection. We aim to investigate the impact of 10 MBL2 gene polymorphisms located in the promoter, 5′UTR and exon 1 regions on HIV-1 physiopathology. The polymorphisms genotyping of 400 individuals, which 200 were HIV-1 positive patients and 200 were controls, was performed by PCR-sequencing. Our results showed that rs503037 and rs1800451 polymorphisms are associated with a high risk of HIV-1 infection susceptibility while rs7096206 and rs11003123 showed a protective effect. A significant association between haplotype CGA and HIV-1 infection susceptibility was also found in the exon 1 region. Moreover, rs11003124, rs7084554, rs36014597 and rs11003123 polymorphisms revealed an association with treatment response outcome as measured by RNA viral load. This study highlights the importance of MBL2 polymorphisms in the modulation of HIV-1 infection susceptibility and the contribution to treatment response outcomes among Moroccan subjects.
ISSN:0198-8859
1879-1166
DOI:10.1016/j.humimm.2022.09.007