Peritubular capillaries of the renal cortex in experimental diabetes mellitus in the rat

Microangiopathy affects the peritubular capillaries in experimental diabetes. Five to six months after streptozotocin administration to induce experimental diabetes in rats, a progressive increase of lymph flow and of the entry of albumin from the renal peritubular capillaries into the interstitium...

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Published inClinical science (1979) Vol. 65; no. 4; pp. 393 - 397
Main Authors PINTER, G. G, STORK, J. E, WILSON, P. D, FAJER, A. B
Format Journal Article
LanguageEnglish
Published London Portland Press 01.10.1983
Subjects
Animals
Biological and medical sciences
Body Weight
Capillary Permeability
Diabetes Mellitus, Experimental - physiopathology
Diabetes. Impaired glucose tolerance
Diabetic Angiopathies - physiopathology
Diabetic Nephropathies - physiopathology
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Kidney Cortex - blood supply
Lymph - metabolism
Lymph - physiology
Medical sciences
Rats
Serum Albumin - metabolism
Endocrinopathy
Vertebrata
Experimental disease
Mammalia
Rat
Diabetes mellitus
Rodentia
Blood capillary
Circulatory system
Renal cortex
Kidney
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Summary:Microangiopathy affects the peritubular capillaries in experimental diabetes. Five to six months after streptozotocin administration to induce experimental diabetes in rats, a progressive increase of lymph flow and of the entry of albumin from the renal peritubular capillaries into the interstitium was seen. Under these conditions, owing to the alteration of peritubular physical forces, the uptake of tubular reabsorbate into the capillaries can be impaired with potentially severe consequences in diabetic nephropathy.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0143-5221
1470-8736
DOI:10.1042/cs0650393