Hypercoagulation from Concomitant Administration of Tamoxifen and Warfarin

Tamoxifen causing an increase in the anticoagulation effect of warfarin is suggested to be clinically significant, but cases so far have been largely undocumented. Current recommendations advise clinicians to proceed with caution during concomitant therapy. In the presence of other medications known...

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Bibliographic Details
Published inCurēus (Palo Alto, CA) Vol. 12; no. 5
Main Authors Panahi, Ladan, Saenz II, Javier A, Nguyen, Nam, Udeani, George, Surani, Salim
Format Journal Article
LanguageEnglish
Published Palo Alto Cureus Inc 14.05.2020
Cureus
Subjects
Antibiotics
Anticoagulants
Antifungal agents
Breast cancer
Case reports
Drug dosages
Enzymes
Hematology
Internal Medicine
Metastasis
Oncology
Patients
Surgery
Thromboembolism
Thrombosis
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Summary:Tamoxifen causing an increase in the anticoagulation effect of warfarin is suggested to be clinically significant, but cases so far have been largely undocumented. Current recommendations advise clinicians to proceed with caution during concomitant therapy. In the presence of other medications known to interact with warfarin, such as antibiotics, proton pump inhibitors, amiodarone, and azole antifungals, international normalized ratio (INR) elevations can possibly be exacerbated even further. We hereby present a case report and a review of significant literature on the use of tamoxifen and warfarin concurrently.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.8114