Effect of timing of cefuroxime dosage on its protection of rats against gentamicin nephrotoxicity

The neophrotoxic effect on rats of once daily treatment with 40 or 45 mg gentamicin/kg/day for ten days was substantially reduced by administration of 4 g cefuroxime/kg/day, either at the same time or eight hours later. This dosage of cefuroxime was protective when given for only two consecutive day...

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Bibliographic Details
Published inInfection Vol. 8; no. 1; p. 41
Main Authors Capel-Edwards, K, Atkinson, R M, Wheeldon, J M, Pratt, D A, Patterson, G G, Harman, I W, Foord, R D
Format Journal Article
LanguageEnglish
Published Germany 1980
Subjects
Animals
Cefuroxime - administration & dosage
Cefuroxime - pharmacology
Cephalosporins - administration & dosage
Gentamicins - metabolism
Gentamicins - toxicity
Kidney - drug effects
Kidney - pathology
Kidney Diseases - chemically induced
Kidney Diseases - prevention & control
Male
Rats
Time Factors
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Summary:The neophrotoxic effect on rats of once daily treatment with 40 or 45 mg gentamicin/kg/day for ten days was substantially reduced by administration of 4 g cefuroxime/kg/day, either at the same time or eight hours later. This dosage of cefuroxime was protective when given for only two consecutive days starting on the first to third days of gentamicin treatment, but enhanced gentamicin nephrotoxocity when started on the sixth or subsequent days.
ISSN:0300-8126
DOI:10.1007/BF01677398