Plant-derived bioactive compounds for the inhibition of biofilm formation: a comprehensive review

• Published in: Environmental science and pollution research international Vol. 31; no. 24; pp. 34859 - 34880
• Main Authors: Er-rahmani, Sara, Errabiti, Badr, Matencio, Adrián, Trotta, Francesco, Latrache, Hassan, Koraichi, Saad Ibnsouda, Elabed, Soumya
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2024; Springer Nature B.V
• Subjects: Aquatic Pollution; Atmospheric Protection/Air Quality Control/Air Pollution; Bioactive compounds; Biofilms; Biofilms - drug effects; Biological activity; Biological Products - chemistry; Biological Products - pharmacology; DNA biosynthesis; Earth and Environmental Science; Ecotoxicology; Environment; Environmental Chemistry; Environmental factors; Environmental Health; Food industry; Hydrophobicity; Microorganisms; Natural products; Oxygen consumption; Pharmacokinetics; Plants; Polymers; Quorum sensing; Quorum Sensing - drug effects; Review Article; Reviews; Waste Water Technology; Water Management; Water Pollution Control; Quorum sensing; Antibiofilm effects; Antibacterial; Biofilm formation; Bioactive compounds; Adhesion
• ISSN: 1614-7499; 0944-1344; 1614-7499
• DOI: 10.1007/s11356-024-33532-2

Biofilm formation is a widespread phenomenon that impacts different fields, including the food industry, agriculture, health care and the environment. Accordingly, there is a serious need for new methods of managing the problem of biofilm formation. Natural products have historically been a rich source of varied compounds with a wide variety of biological functions, including antibiofilm agents. In this review, we critically highlight and discuss the recent progress in understanding the antibiofilm effects of several bioactive compounds isolated from different plants, and in elucidating the underlying mechanisms of action and the factors influencing their adhesion . The literature shows that bioactive compounds have promising antibiofilm potential against both Gram-negative and Gram-positive bacterial and fungal strains, via several mechanisms of action, such as suppressing the formation of the polymer matrix, limiting O 2 consumption, inhibiting microbial DNA replication, decreasing hydrophobicity of cell surfaces and blocking the quorum sensing network. This antibiofilm activity is influenced by several environmental factors, such as nutritional cues, pH values, O 2 availability and temperature. This review demonstrates that several bioactive compounds could mitigate the problem of biofilm production. However, toxicological assessment and pharmacokinetic investigations of these molecules are strongly required to validate their safety.