Application of Nucleic Acid Medicine Using Autologous Serum-derived Small Extracellular Vesicles for Cancer Metastasis

• Published in: Anticancer research Vol. 45; no. 8; pp. 3577 - 3586
• Main Authors: HAZEKAWA, MAI, NISHINAKAGAWA, TAKUYA, ISHIBASHI, DAISUKE
• Format: Journal Article
• Language: English
• Published: Greece International Institute of Anticancer Research 01.08.2025
• Subjects: Acids; Animals; Cancer; Cancer therapies; Cell culture; Drug delivery; Drug delivery systems; Drug Delivery Systems - methods; Drug development; Drug therapy; Efficiency; Extracellular vesicles; Extracellular Vesicles - metabolism; Humans; Lungs; Medical research; Melanoma; Metastases; Metastasis; Neoplasm Metastasis; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - pathology; Neoplasms - therapy; Nucleic acids; Nucleic Acids - administration & dosage; Nucleic Acids - therapeutic use; Particle size; Physical properties; Physicochemical properties; Precision medicine; Tumor cells; extracellular vesicles; metastasis; exosomes; review; siRNA; serum; natural DDS
• ISSN: 0250-7005; 1791-7530; 1791-7530
• DOI: 10.21873/anticanres.17720

Nucleic acids are highly unstable due to their physicochemical properties, presenting a major obstacle to their clinical application as therapeutics. Consequently, the development of drug delivery systems (DDS) is essential to enable stable transport of nucleic acids within the body and to promote efficient cellular uptake. In cancer therapy in particular, selective delivery technologies capable of targeting diseased organs or tumor cells are critical for minimizing off-target effects and reducing adverse events.