Multi-enzyme mimics - cracking the code of subcellular cascade reactions and their potential biological applications
In this review, we discuss the emerging new field of multi-enzyme mimics or multi-nanozymes from a critical perspective portraying the unique characteristics and design strategies that endow a nanomaterial with its multi-enzymatic properties. In order to provide a comprehensive review, distinct and...
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| Published in | Materials chemistry frontiers Vol. 7; no. 15; pp. 337 - 372 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Royal Society of Chemistry
25.07.2023
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| Subjects | |
| Online Access | Get full text |
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| Summary: | In this review, we discuss the emerging new field of multi-enzyme mimics or multi-nanozymes from a critical perspective portraying the unique characteristics and design strategies that endow a nanomaterial with its multi-enzymatic properties. In order to provide a comprehensive review, distinct and widely used nanomaterials such as metals/metal oxides, low dimensional carbons, Prussian blue analogues (PBAs), metal organic frameworks (MOFs), single-atom catalysts (SACs) and smart assemblies/nanohybrids have been selected as the basis for the discussion on transformation of these materials into multi-nanozymes. Studies reported so far on this fascinating new field have been glanced through with a critical perspective and a debate on the limitations, gaps and general misconceptions that can be found related to these nanomaterials and their properties has been initiated. A thorough discussion on the often-confused cascade mechanisms of redox reactions driven by these multi-nanozymes has been brought into the limelight for the first time and the examples of various multi-nanozymes that have been employed in biological applications have been evaluated categorically.
The cascade-like cycle of reactive oxygen species (ROS) generation and consumption by various nanomaterials to mimic multiple natural enzymes depending on the reaction conditions and environmental stimuli. |
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| Bibliography: | Wei Wang is a Professor at the College of Chemical and Biological Engineering, Zhejiang University. He has obtained his PhD in Materials Science in 2010 under the supervision of Prof. Changyou Gao at Zhejiang University, China. He worked in Tianjin University from 2010 to 2020. His research is focused on injectable hydrogels and biomaterials for regenerative medicine. Shichao Sun is currently pursuing his PhD degree under the supervision of Prof. Zhengwei Mao in the Department of Polymer Science and Engineering at Zhejiang University. His research work mainly focuses on the development of metal-based antibacterial nanomaterials and medical devices. Shafaq Sahar is a postdoctoral fellow at the College of Chemical and Biological Engineering, Zhejiang University under the guidance of Prof. Zhengwei Mao and Prof. Wei Wang. She has received her PhD in inorganic chemistry from the University of Science and Technology of China under the supervision of Prof. An-Wu Xu. Her work is focused on the design and engineering of advanced materials such as hydrogels, MOFs and SACs for advanced oxidation processes and their applications in heterogenous catalysis and biomedical, biomimetic and diagnostic applications. An-Wu Xu is a Professor at the Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China. He is a Humboldt Research Fellow and worked at the Max Planck Institute of Colloids and Interfaces, Germany, from 2002 to 2003. His research interests include novel nanostructured materials, biomimetic synthesis and meso-crystal assembly of nanomaterials for various applications including sustained drug and gene delivery, lithium ion batteries, supercapacitors, energy conversion, solar cells and photocatalysis. Zhengwei Mao is currently a Professor and Deputy Director at the Department of Polymer Science and Engineering at Zhejiang University. He obtained his PhD in Materials Science in 2007 from Zhejiang University, China. He worked as a Postdoc under the guidance of Prof. Helmuth Moehwald at the Max Plank Institute of Colloids and Interfaces, Germany. His research is focused on polymeric nanomaterials and seeks to control the microstructure of biomaterials for the purpose of manipulating the cell and tissue response, with the application for cancer therapy, inflammation treatment and tissue regeneration. He also serves as the editor of Acta Biomaterialia. Akif Zeb is an Assistant Research Fellow in the College of Materials Science and Engineering at Hunan University, China, with Prof. Shiguo Zhang. He received his PhD in 2018 in inorganic chemistry from the University of Science and Technology of China and worked in South China Normal University from 2019 to 2022 as Guangdong Talent Postdoc Fellow. His research is focused on the design and development of new materials for energy storage and conversion, heterogeneous catalysis and biomimetics. |
| ISSN: | 2052-1537 2052-1537 |
| DOI: | 10.1039/d2qm01373h |