Ir()-catalyzed decarbonylative annulation of salicylaldehydes with cyclohexane-1,3-diones

An efficient Ir( iii )-catalyzed decarbonylative annulation of salicylaldehydes with cyclohexane-1,3-diones has been achieved via the in situ generated iodonium ylides. The reaction proceeds smoothly under mild and operationally simple conditions, affording a variety of benzofuran derivatives in mod...

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Bibliographic Details
Published inNew journal of chemistry Vol. 47; no. 19; pp. 9421 - 9426
Main Authors Jiang, Qiao-Juan, Min, Yu-Tao, Liu, Yan-Ping, Li, Hua, Peng, Jun-Ao, Liu, Cong-Jun
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 16.05.2023
Royal Society of Chemistry
Subjects
Chemical reactions
Chemistry
Chemistry, Multidisciplinary
Cyclohexane
Diketones
Functional groups
Organic chemistry
Physical Sciences
Science & Technology
MILD
DIVERGENT SYNTHESIS
ALIPHATIC-ALDEHYDES
BENZOFURAN DERIVATIVES
ARYLATION
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Summary:An efficient Ir( iii )-catalyzed decarbonylative annulation of salicylaldehydes with cyclohexane-1,3-diones has been achieved via the in situ generated iodonium ylides. The reaction proceeds smoothly under mild and operationally simple conditions, affording a variety of benzofuran derivatives in moderate to high yields with good functional group tolerance. Moreover, the large-scale synthesis and further modification of the products highlight the utility of this protocol. An efficient Ir( iii )-catalyzed decarbonylative annulation of salicylaldehydes with cyclohexane-1,3-diones has been achieved via the in situ generated iodonium ylides.
Bibliography:Electronic supplementary information (ESI) available. See DOI
https://doi.org/10.1039/d2nj05242c
ISSN:1144-0546
1369-9261
DOI:10.1039/d2nj05242c