Association of VNTR Polymorphims of the Genes Antagonist of Receptor of Interleukin 1 (IL1RN) and Interleukin 4 (IL4) with Dental Caries in Children

• Published in: Russian journal of genetics Vol. 57; no. 10; pp. 1233 - 1237
• Main Authors: Udina, I. G., Vasiliev, Yu. A., Volobuyev, V. V., Gracheva, A. S., Gulenko, O. V.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01.10.2021
• Subjects: Animal Genetics and Genomics; Biomedical and Life Sciences; Biomedicine; Human Genetics; Microbial Genetics and Genomics; Short Communications; cytokine; children; (; ); association; Krasnodar krai; VNTR; caries
• ISSN: 1022-7954; 1608-3369
• DOI: 10.1134/S1022795421100148

In children of Krasnodar krai ( N = 159), association of VNTR polymorphisms of two cytokine genes, antagonist of receptor of interleukin 1 ( IL1RN ) rs2234663 and interleukin 4 ( IL4 ) rs8179190 , with dental caries was studied. In three groups of children with DFC (decompensated form of caries), with SFC (subcompensated form of caries), and with CFC (compensated form of caries) and in healthy children, statistically significant differences were observed between groups by the presence of two “long” alleles L / L of rs2234663 , including found alleles A1 and A4 , between groups of children with CFC and DFC and between SFC and DFC using statistical analysis: OR = 0.33, p = 0.014; 95% CI 0.13–0.87 and OR = 0.35, p = 0.035; 95% CI 0.12–1.00, respectively. The genotypes with two “long” alleles L / L (500 and 410 bp) in genotype were demonstrated mediating resistance to a highly active form of caries, and compound two-locus genotypes by rs2234663 and by rs8179190 ( A1 / A2 P2 / P2 and A2 / A2 P2 / P2 ) and genotypes including at least one allele P2 and one allele A2 (“short”) mediating susceptibility. The group of children with SFC analogous to the group of children with CFC (and healthy) statistically significantly differs from DFC in the same spectrum of the studied VNTR markers of two cytokine genes, which supposes a special role of the studied markers of two cytokine genes in the development of a highly active form of caries.