Genetics, tumor features and treatment response of breast cancer in Latinas

Breast cancer is a heterogeneous and genetic disease that has variability according to ethnicity and race with respect to incidence, clinical characteristics and prognosis. The incidence of breast cancer is lower but mortality is higher in Latinas than Caucasians in the US series. Risk factors appea...

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Bibliographic Details
Published inBreast cancer management Vol. 7; no. 1
Main Authors Castaneda, Carlos A, Castillo, Miluska, Villarreal-Garza, Cynthia, Rabanal, Connie, Dunstan, Jorge, Calderon, Gabriela, La Cruz, Miguel De, Guerra, Henry, Cotrina, Jose M, Abugattas, Julio, Gomez, Henry L
Format Journal Article
LanguageEnglish
Published London Future Medicine Ltd 01.02.2018
Subjects
breast
Breast cancer
cancer
Cancer therapies
Chemotherapy
Ethnicity
Hispanic Americans
Latinas
Medical prognosis
Minority & ethnic groups
Mortality
Mutation
Population
Race
Racial differences
response
Socioeconomic factors
Studies
toxicity
treatment
White people
Brazil
Mexico
Argentina
United States > US
Uruguay
Latin America
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Summary:Breast cancer is a heterogeneous and genetic disease that has variability according to ethnicity and race with respect to incidence, clinical characteristics and prognosis. The incidence of breast cancer is lower but mortality is higher in Latinas than Caucasians in the US series. Risk factors appear to have different prevalence and impact in Latinas. Breast cancer in Latinas has particular clinic-pathological features including younger age, higher rates of triple-negative subtype and advanced stages. Molecular studies find that Latinas from every region have a specific incidence and a recurrent mutation, as well as differences in activity of molecular pathways. Treatment response rates and toxicity have also been compared, and no difference was found between Latinas and other ethnic groups.
ISSN:1758-1923
1758-1931
DOI:10.2217/bmt-2017-0013