Search for Candidate Genes for Mutations Disrupting Synaptonemal Complex Formation in the Sequenced Genome of Rye Secale cereale
The formation of a synaptonemal complex between homologous chromosomes during prophase I of meiosis is of great importance for the normal course of the recombination process. Disruptions in the formation of the synaptonemal complex can lead to both asynapsis (in this case, univalents will be present...
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Published in | Russian journal of genetics Vol. 59; no. 7; pp. 729 - 731 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Moscow
Pleiades Publishing
01.07.2023
|
Subjects | |
Online Access | Get full text |
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Summary: | The formation of a synaptonemal complex between homologous chromosomes during prophase I of meiosis is of great importance for the normal course of the recombination process. Disruptions in the formation of the synaptonemal complex can lead to both asynapsis (in this case, univalents will be present at the metaphase I stage) and heterologous synapsis (both univalents and multivalents will be detected at the metaphase I stage). Previously, we obtained rye mutants in which no formation of synaptonemal complexes (
sy1
and
sy9
) was observed or the synapsis was heterologous (
sy10
,
sy18
, and
sy19
). We performed a bioinformatics analysis of the annotated rye genome and identified potential candidate genes for each of these mutants. The candidate genes were chosen based microsatellite mapping data and their comparison with annotated sequences of the rye genome. As a result, the following genes were selected:
Mei2-like
for the
sy1
mutant,
MAD2
for the
sy9
mutant,
BUB3.3
and
BUB3.1
for
sy10
and
sy18
, respectively, and
Meiosis 5
for
sy19
. |
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ISSN: | 1022-7954 1608-3369 |
DOI: | 10.1134/S1022795423070128 |