Nodular amyloidosis presenting like a primary scarring alopecia

Nodular amyloidosis (NA) is a rare type of primary localized cutaneous amyloidosis in which light chain amyloid deposits in the skin without concurrent systemic involvement. We report a challenging case of NA on the scalp, mimicking primary scarring alopecia, in a relatively young and healthy 36-yea...

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Bibliographic Details
Published inJournal of cutaneous pathology Vol. 50; no. 11; pp. 938 - 941
Main Authors Gulotta, Anthony P, Collins, Joshua M, England, Janessa R, Lew, Jeffrey L, Lee, Christine M
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.11.2023
Subjects
Alopecia
Amyloid
Amyloidosis
Liquid chromatography
Mass spectroscopy
alopecia
light chain amyloidosis
nodular amyloidosis
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Summary:Nodular amyloidosis (NA) is a rare type of primary localized cutaneous amyloidosis in which light chain amyloid deposits in the skin without concurrent systemic involvement. We report a challenging case of NA on the scalp, mimicking primary scarring alopecia, in a relatively young and healthy 36-year-old man. In addition to a nonspecific clinical appearance with a broad differential, NA can be a difficult diagnosis because it may require ancillary testing, such as liquid chromatography-tandem mass spectrometry to type the amyloid protein, and hematology-oncology workup to exclude systemic disease. Pathologists can highlight the importance of systemic evaluation in their reports to ensure patients receive appropriate management.
ISSN:0303-6987
1600-0560
DOI:10.1111/cup.14512