Turnover of catecholamines in torsion dystonia

It is believed that an imbalance of neurotransmitters plays an important role in the pathogenesis of dystonic hyperkinesis. However, the results of different studies on the exchange of catecholamines during dystonia are contradictory. We found a tendency to an increase in the noradrenaline (NA) leve...

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Published inNeurochemical journal Vol. 4; no. 1; pp. 64 - 68
Main Authors Belenky, V. V., Golovkin, V. I., Koroleva, E. M., Verbitskaya, E. V., Klitsenko, O. A., Stanzhevsky, A. A., Tyutin, L. A.
Format Journal Article
LanguageEnglish
Published Dordrecht SP MAIK Nauka/Interperiodica 01.03.2010
Subjects
Biomedical and Life Sciences
Biomedicine
Clinical Neurochemistry
Neurosciences
hyperkinesias
mutation, noradrenaline
homovanillic acid
dystonia
metabolism of catecholamines
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Summary:It is believed that an imbalance of neurotransmitters plays an important role in the pathogenesis of dystonic hyperkinesis. However, the results of different studies on the exchange of catecholamines during dystonia are contradictory. We found a tendency to an increase in the noradrenaline (NA) level and a trend to a decrease in the level of homovanillic acid (HVA) in the blood of patients with dystonia. This finding indicates that the exchange of catecholamines is disturbed during dystonia. However, the changes observed were significant only for some of the statistical methods used; therefore, this problem needs further investigation.
ISSN:1819-7124
1819-7132
DOI:10.1134/S1819712410010113