Salmonella enterica serovar Panama meningitis in exclusive breastfeeding infants: Report of 4 cases, clinical features and therapeutic challenges

• Published in: Medicine (Baltimore) Vol. 96; no. 19; p. e6665
• Main Authors: Elenga, Narcisse, Cuadro, Emma, Long, Laurence, Njuieyon, Falucar, Martin, Elise, Kom-Tchameni, Rémi, Defo, Antoine, Razafindrakoto, Sitraka H, Mrsic, Yajaira, Henaff, Fanny, Mahamat, Aba
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health 01.05.2017
• Subjects: Breast Feeding; Clinical Case Report; Early Diagnosis; Female; Humans; Infant; Male; Meningitis, Bacterial - cerebrospinal fluid; Meningitis, Bacterial - diagnosis; Meningitis, Bacterial - drug therapy; Salmonella enterica; Salmonella Infections - cerebrospinal fluid; Salmonella Infections - diagnosis; Salmonella Infections - drug therapy
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000006665

The pathway of Nontyphoid Salmonella meningitis, especially in exclusive breastfeeding infants, has not been well characterized. We analyzed data related to nontyphoid Salmonella meningitis in 4 infants. No diarrhea was observed and the coproculture was negative for all patients. Early diagnosis and treatment with combination of third-generation cephalosporins plus quinolones for a minimum of 3 weeks is necessary to avoid severe sequelae and death. The first 3 patients had a good evolution, whereas the last patient had multiple brain abscesses and hydrocephalus requiring treatment with a ventriculoperitoneal shunt. The highlights of our study are that all infants were exclusively breastfed, no diarrhea observed and the negative coproculture for all the 4 patients, which is relatively rare for Salmonella infection.