Update on microRNA as biomarkers of adrenocortical cancer: perspective on circulating microRNA

Since my previous editorial on the potential of microRNAs as biomarkers of adrenocortical cancer (ACC) published in International Journal of Endocrine Oncology in 2015 (1), there have been some developments in the field. Recent discoveries have shown that microRNAs are released from cells either via...

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Bibliographic Details
Published inInternational journal of endocrine oncology Vol. 4; no. 1; pp. 1 - 3
Main Author Igaz, Peter
Format Journal Article
LanguageEnglish
Published London Future Medicine Ltd 01.03.2017
Subjects
adrenocortical cancer
biomarker
Biomarkers
Biopsy
Cancer therapies
Chemotherapy
circulating microRNA
Disease
Epigenetics
Gene expression
Hypotheses
malignancy
Medical prognosis
MicroRNAs
Neuroendocrine tumors
Pathogenesis
Studies
Surveillance
therapy monitoring
Tumors
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Summary:Since my previous editorial on the potential of microRNAs as biomarkers of adrenocortical cancer (ACC) published in International Journal of Endocrine Oncology in 2015 (1), there have been some developments in the field. Recent discoveries have shown that microRNAs are released from cells either via passive (e.g., necrosis, inflammation) or active secretion; active secretion of microRNAs occurs either in extracellular membrane vesicles (microvesicles, exosomes, apoptotic bodies) or in macromolecular complexes (e.g., complexed with Argonaute 2 protein or high density lipoprotein) (8). Since microRNAs are involved in the regulation of gene expression forming part of the epigenetic machinery, extracellular microRNA profiles might convey valuable information on cellular functioning. [...]we have found much fewer significantly differentially expressed microRNAs in extracellular vesicle preparations than in unfractionated plasma that might also confirm our hypothesis that extracellular vesicles could be more specific as a source of microRNAs (Perge et al. [...]circulating microRNAs might be promising minimally invasive biomarkers of ACC and as markers of malignancy, prognosis and even applicable for monitoring the efficacy of anticancer treatment.
Bibliography:SourceType-Scholarly Journals-1
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ObjectType-Editorial-2
ObjectType-Commentary-1
ISSN:2045-0869
2045-0877
DOI:10.2217/ije-2017-0001