Facile construction of 2-pyrones under carbene catalysis

2-Pyrones are valuable structural motifs in organic chemistry, found in numerous natural products and pharmaceuticals. The synthesis of these heterocycles has been significantly advanced by the application of N-Heterocyclic Carbene (NHC) catalysis. This review examines the recent advancements in NHC...

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Bibliographic Details
Published inRSC advances Vol. 14; no. 39; pp. 28585 - 28595
Main Authors Yu, Miao, Huang, Jie, Zhu, Haibin, Shi, Dongping, Yang, Weiqi, Liu, Yingjie, Ji, Yubin, Fu, Zhenqian
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 04.09.2024
Subjects
Carbenes
Catalysis
Chemical synthesis
Natural products
Organic chemistry
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Summary:2-Pyrones are valuable structural motifs in organic chemistry, found in numerous natural products and pharmaceuticals. The synthesis of these heterocycles has been significantly advanced by the application of N-Heterocyclic Carbene (NHC) catalysis. This review examines the recent advancements in NHC-catalyzed synthesis of 2-pyrones, highlighting key methodologies, mechanisms, and synthetic applications. NHC catalysis has revolutionized the synthesis of 2-pyrones, providing efficient, selective, and versatile methods for constructing these valuable heterocycles.
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ISSN:2046-2069
2046-2069
DOI:10.1039/d4ra05596a