Carcinogenicity of 1,2-dimethylhydrazine dihydrochloride in BALB/c mice. Influence of the route of administration and dosage

The carcinogenicity of 1,2-dimethylhydrazine dihydrochloride (DMH) by oral, intragastric and subcutaneous administration was examined in 339 BALB/c mice. Subcutaneous injection of DMH induced intestinal tumors in the lower colon of all mice. After oral administration it induced a high incidence of v...

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Bibliographic Details
Published inVirchows Archiv. A. Pathological anatomy and histology Vol. 384; no. 3; p. 263
Main Authors Izumi, K, Otsuka, H, Furuya, K, Akagi, A
Format Journal Article
LanguageEnglish
Published Germany 01.10.1979
Subjects
Administration, Oral
Animals
Colonic Neoplasms - chemically induced
Dimethylhydrazines - administration & dosage
Dimethylhydrazines - pharmacology
Female
Injections, Subcutaneous
Intubation, Gastrointestinal
Liver Neoplasms - chemically induced
Male
Methylhydrazines - administration & dosage
Mice
Mice, Inbred BALB C
Neoplasms, Vascular Tissue - chemically induced
Soft Tissue Neoplasms - chemically induced
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Summary:The carcinogenicity of 1,2-dimethylhydrazine dihydrochloride (DMH) by oral, intragastric and subcutaneous administration was examined in 339 BALB/c mice. Subcutaneous injection of DMH induced intestinal tumors in the lower colon of all mice. After oral administration it induced a high incidence of vascular tumors in the liver and soft tissues, but colon tumors were found in only 2 mice when given at a high dosage. On intragastric administration, it induced a fairly high incidence both of colon and vascular tumors. The sites and incidences of vascular tumors and squamous cell carcinomas of the perianal glands were also described.
ISSN:0340-1227
DOI:10.1007/BF00428228