Pseudomonas aeruginosa Biofilm: A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms (Adv. Sci. 12/2021)

• Published in: Advanced science Vol. 8; no. 12
• Main Authors: Schütz, Christian, Ho, Duy‐Khiet, Hamed, Mostafa Mohamed, Abdelsamie, Ahmed Saad, Röhrig, Teresa, Herr, Christian, Kany, Andreas Martin, Rox, Katharina, Schmelz, Stefan, Siebenbürger, Lorenz, Wirth, Marius, Börger, Carsten, Yahiaoui, Samir, Bals, Robert, Scrima, Andrea, Blankenfeldt, Wulf, Horstmann, Justus Constantin, Christmann, Rebekka, Murgia, Xabier, Koch, Marcus, Berwanger, Aylin, Loretz, Brigitta, Hirsch, Anna Katharina Herta, Hartmann, Rolf Wolfgang, Lehr, Claus‐Michael, Empting, Martin
• Format: Journal Article
• Language: English
• Published: Weinheim John Wiley & Sons, Inc 01.06.2021; John Wiley and Sons Inc
• Subjects: Frontispiece
• ISSN: 2198-3844; 2198-3844
• DOI: 10.1002/advs.202170069

In article number 2004369, Martin Empting and colleagues describe a new generation of dual‐loaded nanoparticles enabling efficient eradication of Pseudomonas aeruginosa biofilms. The squalene‐based nanocarrier facilitates co‐delivery of a novel pathogenspecific Quorum Sensing Inhibitor (QSI) together with the standard‐of‐care antibiotic tobramycin. The QSI itself shows high anti‐virulence efficacy, favorable DMPK and no overt safety pharmacology. When applied as the nanoparticle formulation the QSI potentiates biofilm eradication capabilities of tobramycin by at least 32‐fold.