Alternative to steroid therapy for myasthenia gravis and myositis occurring as immune‐related adverse events

We experienced a case of generalized myasthenia gravis and myositis occurring as immune‐related adverse events that was curable without steroid therapy, only through the discontinuation of immune checkpoint inhibitor. Although the patient did not receive cancer treatment afterwards, her cancer remai...

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Published inClinical & experimental neuroimmunology Vol. 10; no. 3; pp. 190 - 191
Main Authors Kamada, Sachiko, Hanazono, Akira, Sanpei, Yui, Inoue, Takamitsu, Suzuki, Shigeaki, Sugawara, Masashiro, Iijima, Katsunori
Format Journal Article
LanguageEnglish
Published Ube Wiley Subscription Services, Inc 01.08.2019
Subjects
anti‐striational antibodies
Cancer
Cancer immunotherapy
immune checkpoint inhibitor
Immune checkpoint inhibitors
immune‐related adverse events
Immunotherapy
Inflammatory diseases
Musculoskeletal diseases
Myasthenia
Myasthenia gravis
Myositis
Neuromuscular junctions
steroids
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Summary:We experienced a case of generalized myasthenia gravis and myositis occurring as immune‐related adverse events that was curable without steroid therapy, only through the discontinuation of immune checkpoint inhibitor. Although the patient did not receive cancer treatment afterwards, her cancer remained stable. We emphasize that not selecting steroid therapy might enhance the effect of cancer immunotherapy.
ISSN:1759-1961
1759-1961
DOI:10.1111/cen3.12526