Transforming growth factor‐β, interleukin‐17, and IL‐23 gene expression profiles associated with human peri‐implantitis
Objectives The mRNA expression profiles of IL‐23/Th17 and the Treg‐associated cytokine TGF‐β in peri‐implantitis are currently under research. This study characterized the IL‐17, IL‐23, and TGF‐β gene expression levels in healthy and diseased peri‐implant tissues and correlated these data with radio...
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Published in | Clinical oral implants research Vol. 28; no. 7; pp. e10 - e15 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Denmark
01.07.2017
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Subjects | |
Online Access | Get full text |
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Summary: | Objectives
The mRNA expression profiles of IL‐23/Th17 and the Treg‐associated cytokine TGF‐β in peri‐implantitis are currently under research. This study characterized the IL‐17, IL‐23, and TGF‐β gene expression levels in healthy and diseased peri‐implant tissues and correlated these data with radiographic bone loss.
Material and Methods
Peri‐implant soft tissues from 40 subjects (20 healthy controls with mean age of 59.4 ± 6.3, and 20 with peri‐implantitis with mean age of 56.6 ± 5.5) were enrolled in this study, and real‐time PCR (RT‐PCR) was used to define the profile of IL‐17, IL‐23, and TGF‐β gene expression.
Results
Higher levels of TGF‐β mRNA were observed in biopsies taken from healthy controls, and the IL‐23 mRNA levels were significantly increased in the peri‐implantitis group (P < 0.0001). No differences in IL‐17 mRNA levels were observed between the two groups (P > 0.05).
Conclusions
Data presented in this report demonstrated a predominant Th17 response in peri‐implantitis subjects based on the higher levels of IL‐23 and lower levels of TGF‐β detected. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0905-7161 1600-0501 |
DOI: | 10.1111/clr.12846 |