Atherosclerosis and Thrombosis -with special reference to the role of thrombi in the development of atherosclerosis
Various hypotheses have been advanced concerning the pathogenesis of atherosclerosis especially as regards the initiating event. Two opposing theories are prevalent today, each supported by considerable evidence. The proponents of one theory hold that arterial plaque formation is initiated by deposi...
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| Published in | Japanese Journal of Medicine Vol. 2; no. 4; pp. 525 - 533 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
The Japanese Society of Internal Medicine
1963
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| Online Access | Get full text |
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| Summary: | Various hypotheses have been advanced concerning the pathogenesis of atherosclerosis especially as regards the initiating event. Two opposing theories are prevalent today, each supported by considerable evidence. The proponents of one theory hold that arterial plaque formation is initiated by deposition of lip id beneath the endothelial lining cells. The proponents of the opposing other theory hold that the plaque formation is initiated by the deposition of fibrin on the endothelial surface, which is incorporated into the intima. This report is concerned with the role of thrombosis or fibrin deposits in the pathogenesis of atherosclerosis. |
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| ISSN: | 0021-5120 1881-123X |
| DOI: | 10.2169/internalmedicine1962.2.525 |