Islet transplantation in experimental diabetes of the rat. VII. Cryopreservation of rat and human islets. Preliminary results

Islet transplantation in human diabetes at present is confronted with two major obstacles: isolation of a sufficient number of islets and islet graft rejection. "Tissue banking" would enable islet pooling from various donors and offers furthermore the advantage of in vitro manipulations in...

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Published inHormone and metabolic research Vol. 12; no. 6; p. 274
Main Authors Bretzel, R G, Schneider, J, Dobroschke, J, Schwemmle, K, Pfeiffer, E F, Federlin, K
Format Journal Article
LanguageEnglish
Published Germany 1980
Subjects
Animals
Blood Glucose - analysis
Body Weight
Diabetes Mellitus, Experimental - therapy
Freezing
Glycosuria
Humans
Insulin - blood
Islets of Langerhans - ultrastructure
Islets of Langerhans Transplantation
Rats
Tissue Preservation
Transplantation, Homologous
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Summary:Islet transplantation in human diabetes at present is confronted with two major obstacles: isolation of a sufficient number of islets and islet graft rejection. "Tissue banking" would enable islet pooling from various donors and offers furthermore the advantage of in vitro manipulations in order to reduce islet immunogenicity. Recently we have reported successful cryopreservation and subsequent transplantation of porcine islets (Bretzel, Beule, Schäfer, Schneider, Pfeiffer and Federlin 1979). These preliminary data deal with cryopreservation and transplantation of isolated rat islets and cryopreservation of isolated human islets.
ISSN:0018-5043
DOI:10.1055/s-2007-996265