Upbeat nystagmus at caudal brainstem lesions in four cases with multiple sclerosis and its related disorders

Upbeat nystagmus (UBN) is relatively rare. Little is known about UBN in acute central nervous system inflammatory disorders, including multiple sclerosis (MS), neuromyelitis optica (NMO) and related disorders. We investigated two patients with MS, one with clinically isolated syndrome and one with b...

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Bibliographic Details
Published inClinical & experimental neuroimmunology Vol. 4; no. 2; pp. 206 - 209
Main Authors Uzawa, Akiyuki, Mori, Masahiro, Masuda, Saeko, Muto, Mayumi, Uchida, Tomohiko, Kuwabara, Satoshi
Format Journal Article
LanguageEnglish
Published Ube Wiley Subscription Services, Inc 01.08.2013
Subjects
brainstem
magnetic resonance imaging
Medical research
Multiple sclerosis
neuromyelitis optica
nystagmus
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Summary:Upbeat nystagmus (UBN) is relatively rare. Little is known about UBN in acute central nervous system inflammatory disorders, including multiple sclerosis (MS), neuromyelitis optica (NMO) and related disorders. We investigated two patients with MS, one with clinically isolated syndrome and one with brainstem inflammation possibly related to NMO who developed UBN because of brainstem lesions. Three of the four patients presented caudal medulla lesions and one presented a caudal pontomesencephalic lesion on magnetic resonance imaging. Caudal brainstem lesions may cause UBN in these disorders, probably by impairing the ventral tegmental tract.
ISSN:1759-1961
1759-1961
DOI:10.1111/cen3.12013