Microfluidic Chips: An Early-Stage Atherosclerosis Research Model Based on Microfluidics (Small 15/2016)
On page 2022, a microfluidic atherosclerosis (AS) model reconstituting early‐stage AS is designed by X. Jiang and co‐workers. Physiological or AS‐prone hemodynamic conditions are recapitulated on the model. Under a hemodynamic background, AS‐prone biochemical factors such as hyperglycemia, hyperlipi...
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| Published in | Small (Weinheim an der Bergstrasse, Germany) Vol. 12; no. 15; p. 1961 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Weinheim
Blackwell Publishing Ltd
01.04.2016
Wiley Subscription Services, Inc |
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| Abstract | On page 2022, a microfluidic atherosclerosis (AS) model reconstituting early‐stage AS is designed by X. Jiang and co‐workers. Physiological or AS‐prone hemodynamic conditions are recapitulated on the model. Under a hemodynamic background, AS‐prone biochemical factors such as hyperglycemia, hyperlipidemia, angiotensin‐II, tumor necrosis factor‐α (TNF‐α) and lipopolysaccharides lead to dysfunction of the endothelial cells. The on‐chip model recaptures the atherogenic responses of endothelial cells in ways that a Petri dish cannot. Platinum nanoparticles (Pt‐NPs) can treat AS‐prone pathology on the model, which is in good agreement with the results on mouse. |
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| AbstractList | On page 2022, a microfluidic atherosclerosis (AS) model reconstituting early‐stage AS is designed by X. Jiang and co‐workers. Physiological or AS‐prone hemodynamic conditions are recapitulated on the model. Under a hemodynamic background, AS‐prone biochemical factors such as hyperglycemia, hyperlipidemia, angiotensin‐II, tumor necrosis factor‐α (TNF‐α) and lipopolysaccharides lead to dysfunction of the endothelial cells. The on‐chip model recaptures the atherogenic responses of endothelial cells in ways that a Petri dish cannot. Platinum nanoparticles (Pt‐NPs) can treat AS‐prone pathology on the model, which is in good agreement with the results on mouse. On page 2022, a microfluidic atherosclerosis (AS) model reconstituting early-stage AS is designed by X. Jiang and co-workers. Physiological or AS-prone hemodynamic conditions are recapitulated on the model. Under a hemodynamic background, AS-prone biochemical factors such as hyperglycemia, hyperlipidemia, angiotensin-II, tumor necrosis factor-[alpha] (TNF-[alpha]) and lipopolysaccharides lead to dysfunction of the endothelial cells. The on-chip model recaptures the atherogenic responses of endothelial cells in ways that a Petri dish cannot. Platinum nanoparticles (Pt-NPs) can treat AS-prone pathology on the model, which is in good agreement with the results on mouse. |
| Author | Jiang, Bo Zhao, Yuyun Jiang, Xingyu Huang, Rong Zheng, Wenfu Zhang, Wei |
| Author_xml | – sequence: 1 givenname: Wenfu surname: Zheng fullname: Zheng, Wenfu organization: Beijing Engineering Research Center for BioNanotechnology, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, No.11 BeiYiTiao, ZhongGuanCun, 100190, Beijing, P. R. China – sequence: 2 givenname: Rong surname: Huang fullname: Huang, Rong organization: College of Physics and Collaborative Innovation Center for Marine Biomass Fibers, Materials and Textiles of Shandong Province, Qingdao University, No. 308 Ningxia Road, 266071, Qingdao, China – sequence: 3 givenname: Bo surname: Jiang fullname: Jiang, Bo organization: Beijing Engineering Research Center for BioNanotechnology, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, No.11 BeiYiTiao, ZhongGuanCun, 100190, Beijing, P. R. China – sequence: 4 givenname: Yuyun surname: Zhao fullname: Zhao, Yuyun organization: Beijing Engineering Research Center for BioNanotechnology, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, No.11 BeiYiTiao, ZhongGuanCun, 100190, Beijing, P. R. China – sequence: 5 givenname: Wei surname: Zhang fullname: Zhang, Wei organization: Beijing Engineering Research Center for BioNanotechnology, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, No.11 BeiYiTiao, ZhongGuanCun, 100190, Beijing, P. R. China – sequence: 6 givenname: Xingyu surname: Jiang fullname: Jiang, Xingyu organization: Beijing Engineering Research Center for BioNanotechnology, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, No.11 BeiYiTiao, ZhongGuanCun, 100190, Beijing, P. R. China |
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| Copyright | 2016 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim Copyright © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
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| Snippet | On page 2022, a microfluidic atherosclerosis (AS) model reconstituting early‐stage AS is designed by X. Jiang and co‐workers. Physiological or AS‐prone... On page 2022, a microfluidic atherosclerosis (AS) model reconstituting early-stage AS is designed by X. Jiang and co-workers. Physiological or AS-prone... |
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| StartPage | 1961 |
| SubjectTerms | Atherosclerosis blood vessels drug screening mechanics microfluidic chips Nanotechnology Rodents Tumor necrosis factor-TNF |
| Title | Microfluidic Chips: An Early-Stage Atherosclerosis Research Model Based on Microfluidics (Small 15/2016) |
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