Microfluidic Chips: An Early-Stage Atherosclerosis Research Model Based on Microfluidics (Small 15/2016)

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 12; no. 15; p. 1961
• Main Authors: Zheng, Wenfu, Huang, Rong, Jiang, Bo, Zhao, Yuyun, Zhang, Wei, Jiang, Xingyu
• Format: Journal Article
• Language: English
• Published: Weinheim Blackwell Publishing Ltd 01.04.2016; Wiley Subscription Services, Inc
• Subjects: Atherosclerosis; blood vessels; drug screening; mechanics; microfluidic chips; Nanotechnology; Rodents; Tumor necrosis factor-TNF
• ISSN: 1613-6810; 1613-6829
• DOI: 10.1002/smll.201670073

On page 2022, a microfluidic atherosclerosis (AS) model reconstituting early‐stage AS is designed by X. Jiang and co‐workers. Physiological or AS‐prone hemodynamic conditions are recapitulated on the model. Under a hemodynamic background, AS‐prone biochemical factors such as hyperglycemia, hyperlipidemia, angiotensin‐II, tumor necrosis factor‐α (TNF‐α) and lipopolysaccharides lead to dysfunction of the endothelial cells. The on‐chip model recaptures the atherogenic responses of endothelial cells in ways that a Petri dish cannot. Platinum nanoparticles (Pt‐NPs) can treat AS‐prone pathology on the model, which is in good agreement with the results on mouse.