Usefulness of methods to detect hepatitis virus E infection for case notifications

We determined the presence of anti-HEV IgM antibody, anti-HEV IgA antibody, and HEV RNA in serum samples of 73 notified cases that were recorded on the day of disease onset. HEV RNA was detectable until 3 weeks after disease onset. Both IgM and IgA anti-HEV antibodies were positive until 40 days aft...

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Bibliographic Details
Published inKanzo Vol. 60; no. 1; pp. 23 - 30
Main Authors Ishida, Setsuko, Yoshizumi, Shima, Matsubayashi, Keiji, Sakata, Hidekatsu, Nagano, Hideki
Format Journal Article
LanguageEnglish
Japanese
Published The Japan Society of Hepatology 18.01.2019
Subjects
anti-HEV IgA antibody
anti-HEV IgM antibody
genotype
hepatitis E
hepatitis E virus
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Summary:We determined the presence of anti-HEV IgM antibody, anti-HEV IgA antibody, and HEV RNA in serum samples of 73 notified cases that were recorded on the day of disease onset. HEV RNA was detectable until 3 weeks after disease onset. Both IgM and IgA anti-HEV antibodies were positive until 40 days after the disease onset. Among the HEV RNA positive patients, 41 out of 60 symptomatic and 2 out of 54 asymptomatic ones had genotype 4 HEV, respectively. Only 23.3% (14/60) of HEV RNA positive patients in the asymptomatic group were confirmed the presence of anti-HEV antibodies. Testing for the presence of both anti-HEV antibodies and HEV RNA would be beneficial for the comprehensive diagnosis of hepatitis E infections.
ISSN:0451-4203
1881-3593
DOI:10.2957/kanzo.60.23