Aphthous lesions turned out to be neonatal very early-onset inflammatory bowel disease: a case report

Neonatal diagnosis of inflammatory bowel disease (IBD) proves challenging due to its non-specific symptoms. A term-born neonate showing states of inflammation and aphthae was treated for sepsis and candidiasis before being diagnosed with interleukin-10 receptor deficiency and consecutive IBD. The pa...

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Published inFrontiers in pediatrics Vol. 12; p. 1433852
Main Authors Hutmacher, Felix, Doerig, Selina, Grobholz, Rainer, Köhler, Henrik, Meyer, Philipp, Baumann, Philipp
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 30.10.2024
Subjects
candida
case report
inflammatory bowel diseases
newborn
oesophagitis
Pediatrics
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Summary:Neonatal diagnosis of inflammatory bowel disease (IBD) proves challenging due to its non-specific symptoms. A term-born neonate showing states of inflammation and aphthae was treated for sepsis and candidiasis before being diagnosed with interleukin-10 receptor deficiency and consecutive IBD. The patient was finally successfully treated by stem cell transplantation. The case illustrates the difficulties of the diagnostic course in IBD as it may mimic other diseases and emphasizes the importance of considering rare differential diagnoses early in the diagnostic process.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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Edited by: Paul Rufo, Boston Children's Hospital and Harvard Medical School, United States
Present Address Philipp Baumann, Department of Intensive Care and Neonatology, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland
Gabriele Stocco, University of Trieste, Italy
These authors have contributed equally to this work and share first authorship
Reviewed by: Samuele Naviglio, Institute for Maternal and Child Health Burlo Garofolo (IRCCS), Italy
ISSN:2296-2360
2296-2360
DOI:10.3389/fped.2024.1433852