Production of enterotoxin by Vibrio vulnificus isolates

Weakly virulent isolates of Vibrio vulnificus that were lethal only to simultaneously iron-overloaded and immunosuppressed mice were tested for ability to cause fluid accumulation in the permanently ligated rabbit ileal loop. Unlike the highly virulent isolates, which caused septicemia and death in...

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Bibliographic Details
Published inJournal of food protection Vol. 51; no. 3; pp. 192 - 196
Main Authors Stelma, G.N. Jr, Spaulding, P.L, Reyes, A.L, Johnson, C.H
Format Journal Article
LanguageEnglish
Published Des Moines, IA International Association of Milk, Food and Environmental Sanitarians 01.03.1988
Subjects
Biological and medical sciences
CONEJO (ORYCTOLAGUS)
ENTEROTOXINAS
ENTEROTOXINE
ENTEROTOXINS
FLUIDE
FLUIDOS
FLUIDS
Food industries
Food microbiology
Fundamental and applied biological sciences. Psychology
INTESTIN
INTESTINES
INTESTINOS
LAPIN
PATHOGENICITY
PODER PATOGENO
POUVOIR PATHOGENE
RABBITS
VIBRIO
Toxicology
Toxicity
Enterotoxin
Bacteria
Vibrionaceae
Biosynthesis
Vibrio
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Summary:Weakly virulent isolates of Vibrio vulnificus that were lethal only to simultaneously iron-overloaded and immunosuppressed mice were tested for ability to cause fluid accumulation in the permanently ligated rabbit ileal loop. Unlike the highly virulent isolates, which caused septicemia and death in rabbits, these isolates caused significant fluid accumulation in the rabbit loops. Fluid accumulation was also observed when culture filtrates were tested, indicating the existence of an enterotoxin. Enterotoxin activity did not correlate with the hemolysin or protease activities. Only one of three enterotoxigenic isolates caused diarrhea when administered to temporarily ligated rabbit ileal loops, suggesting involvement of some other pathogenic determinant(s) such as colonization.
Bibliography:Q03
8833987
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ISSN:0362-028X
1944-9097
DOI:10.4315/0362-028X-51.3.192