Efficacy of Lobelia alsinoides Lam ethanolic extract on a third‐degree burn: An experimental study on rats

• Published in: Dermatologic therapy Vol. 33; no. 6; pp. e14242 - n/a
• Main Authors: Samdavid Thanapaul, Rex Jeya Rajkumar, Ranjan, Abraham, Manikandan, Sreeraj K., Nadar, M. S. A. Muthukumar
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.11.2020
• Subjects: Animals; burn wound; Burns - drug therapy; Eschar; Lobelia; Lobelia alsinoides Lam; Male; ointment; Plant Extracts; Rats; Rats, Wistar; Wound Healing; burn wound; wound healing; Eschar; ointment; Lobelia alsinoides Lam
• ISSN: 1396-0296; 1529-8019; 1529-8019
• DOI: 10.1111/dth.14242

This is the first study to evaluate the topical application of Lobelia alsinoides Lam (LT) ethanolic extract on burns in rats. A deep third‐degree burn wound was inflicted in adult male Wistar rats and the burns were dressed daily with a topical ointment formulation (Patent filed) comprising of Lobelia alsinoides Lam (5% and 10% w/w). The wound had noteworthy contraction and quicker eschar removal in 10% w/w LT‐treated groups followed by 5% w/w treated groups on comparing with the commonly prescribed ointment (SilverexTM containing 1% w/w Silver sulfadiazine). Histopathological analysis showed that ointment containing 10% w/w LT ethanolic extract significantly increased fibroblast growth, which plays a major role in anatomic integrity, collagen synthesis, and accelerated the rate of the healing process. This study shows that the ethanolic extract of Lobelia alsinoides Lam, a previously pharmacologically unreported traditional medicinal plant, possesses wound contraction and eschar removal properties on burn wounds.