Imidazoline 2 binding sites reflecting astroglia pathology in Parkinson’s disease: an in vivo11C-BU99008 PET study

Do astrocytes play a role in the initiation and progression of Parkinson’s disease? Wilson et al. reveal activation of astrocytes in early Parkinson’s disease, likely in response to the presence of abnormal proteins. Loss of astrocytes occurs upon disease progression, however, and correlates with in...

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Bibliographic Details
Published inBrain (London, England : 1878) Vol. 142; no. 10; pp. 3116 - 3128
Main Authors Wilson, Heather, Dervenoulas, George, Pagano, Gennaro, Tyacke, Robin J, Polychronis, Sotirios, Myers, Jim, Gunn, Roger N, Rabiner, Eugenii A, Nutt, David, Politis, Marios
Format Journal Article
LanguageEnglish
Published England 01.10.2019
Subjects
Aged
Astrocytes - metabolism
Astrocytes - pathology
Binding Sites
Brain - metabolism
Carbon Radioisotopes - metabolism
Female
Gray Matter - metabolism
Humans
Imidazoles
Imidazoline Receptors - metabolism
Imidazoline Receptors - physiology
Imidazolines - metabolism
Indoles
Magnetic Resonance Imaging
Male
Middle Aged
Parkinson Disease - metabolism
Parkinson Disease - pathology
Positron Emission Tomography Computed Tomography - methods
Protein Binding - physiology
Temporal Lobe - metabolism
astroglia
positron emission tomography
neuroinflammation
imidazoline 2 binding sites
Parkinson’s disease
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Summary:Do astrocytes play a role in the initiation and progression of Parkinson’s disease? Wilson et al. reveal activation of astrocytes in early Parkinson’s disease, likely in response to the presence of abnormal proteins. Loss of astrocytes occurs upon disease progression, however, and correlates with increasing cognitive impairment.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0006-8950
1460-2156
1460-2156
DOI:10.1093/brain/awz260