Immune cell triads reprogram exhausted CD8+ T cells for effective tumor elimination

In this issue of Cancer Cell, Espinosa-Carrasco et al. show that the efficacy of cancer immunotherapies depends upon the formation of intratumoral immune triads between antigen-presenting cells and antigen-specific CD4+ and CD8+ T cells. This interaction reprograms tumor-specific CD8+ T cells to exe...

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Bibliographic Details
Published inCancer cell Vol. 42; no. 7; pp. 1152 - 1154
Main Authors Lise, Veronica, Malenica, Ines, Roychoudhuri, Rahul, Lugli, Enrico
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 08.07.2024
Subjects
Animals
Antigen-Presenting Cells - immunology
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Humans
Immunotherapy - methods
Mice
Neoplasms - immunology
Neoplasms - therapy
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Summary:In this issue of Cancer Cell, Espinosa-Carrasco et al. show that the efficacy of cancer immunotherapies depends upon the formation of intratumoral immune triads between antigen-presenting cells and antigen-specific CD4+ and CD8+ T cells. This interaction reprograms tumor-specific CD8+ T cells to exert potent effector functions and eradicate established solid tumors. In this issue of Cancer Cell, Espinosa-Carrasco et al. show that the efficacy of cancer immunotherapies depends upon the formation of intratumoral immune triads between antigen-presenting cells and antigen-specific CD4+ and CD8+ T cells. This interaction reprograms tumor-specific CD8+ T cells to exert potent effector functions and eradicate established solid tumors.
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ISSN:1535-6108
1878-3686
1878-3686
DOI:10.1016/j.ccell.2024.06.010