Fasicularin, a novel tricyclic alkaloid from the ascidian Nephteis fasicularis with selective activity against a DNA repair-deficient organism

A novel tricyclic alkaloid, fasicularin ( 1), was isolated from the Micronesian ascidian Nephteis fasicularis. The structure of 1 was elucidated primarily by interpretation of spectral data. Fasicularin was found to be active in a DNA damaging assay. A novel tricyclic alkaloid, fasicularin, was isol...

Full description

Saved in:
Bibliographic Details
Published inTetrahedron letters Vol. 38; no. 3; pp. 363 - 364
Main Authors Patil, Ashok D., Freyer, Alan J., Reichwein, Rex, Carte, Brad, Killmer, Lewis B., Faucette, Leo, Johnson, Randall K., Faulkner, D.John
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 1997
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
CLAVELINA-CYLINDRICA
Online AccessGet full text

Cover

More Information
Summary:A novel tricyclic alkaloid, fasicularin ( 1), was isolated from the Micronesian ascidian Nephteis fasicularis. The structure of 1 was elucidated primarily by interpretation of spectral data. Fasicularin was found to be active in a DNA damaging assay. A novel tricyclic alkaloid, fasicularin, was isolated from the Micronesian ascidian Naphteis fasicularis. The structure of fasicularin was elucidated primarily by interpretation of spectral data. Fasicularin was found to be active in DNA damaging assay.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(96)02304-0