Epidemiology of persistent proteinuria in type II diabetes mellitus. Population-based study in Rochester, Minnesota
Epidemiology of persistent proteinuria in type II diabetes mellitus. Population-based study in Rochester, Minnesota. D J Ballard , L L Humphrey , L J Melton, 3rd , P P Frohnert , P C Chu , W M O'Fallon and P J Palumbo Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905. Abs...
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Published in | Diabetes (New York, N.Y.) Vol. 37; no. 4; pp. 405 - 412 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
American Diabetes Association
01.04.1988
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Online Access | Get full text |
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Summary: | Epidemiology of persistent proteinuria in type II diabetes mellitus. Population-based study in Rochester, Minnesota.
D J Ballard ,
L L Humphrey ,
L J Melton, 3rd ,
P P Frohnert ,
P C Chu ,
W M O'Fallon and
P J Palumbo
Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905.
Abstract
Clinical risk factors for nephropathy were assessed in a population-based study of Rochester, Minnesota, residents with diabetes
mellitus initially diagnosed between 1945 and 1969 (incidence cohort). The 1031 Rochester residents with non-insulin-dependent
diabetes mellitus (NIDDM) were followed through their complete medical records in the community to 1 January 1982. The prevalence
of persistent proteinuria was 8.2% at the diagnosis of NIDDM. Among those initially free of persistent proteinuria, the subsequent
incidence was 15.3/1000 person-yr. Twenty years after the diagnosis of diabetes, the cumulative incidence of persistent proteinuria
was 24.6%. A proportional hazards model identified the following risk factors for persistent proteinuria in NIDDM: elevated
initial fasting blood glucose (P less than .01); older age at onset of diabetes (P less than .01); male gender (P = .05);
and presence of macrovascular disease (P = .05), diabetic retinopathy (P = .05), or glycosuria (P = .07) at the diagnosis
of diabetes. Separate analyses controlling for attained age indicated no association between duration of NIDDM and the incidence
of persistent proteinuria. Stratified analysis of the two most significant risk factors (fasting blood glucose and age) indicated
that hyperglycemia was a stronger risk factor for proteinuria in younger diabetic subjects, perhaps because of a competing
risk of death in the elderly diabetic patient. In contrast to a recently described decreasing secular trend of proteinuria
in Danish insulin-dependent diabetes mellitus patients, there was no decrease over the past 40 yr in proteinuria risk in this
NIDDM incidence cohort. |
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ISSN: | 0012-1797 1939-327X 0012-1797 |
DOI: | 10.2337/diabetes.37.4.405 |