Skeletal muscle hypertrophy: cell growth is cell growth

Roberts et al. have provided an insightful counterpoint to our review article on the utility of the synergist ablation model. The purpose of this review is to provide some further dialogue regarding the strengths and weaknesses of the synergist ablation model. Specifically, we highlight that the rob...

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Bibliographic Details
Published inAmerican Journal of Physiology: Cell Physiology Vol. 327; no. 3; pp. C614 - C618
Main Authors Burke, Benjamin I., Ismaeel, Ahmed, von Walden, Ferdinand, Murach, Kevin A., McCarthy, John J.
Format Journal Article
LanguageEnglish
Published Bethesda American Physiological Society 01.09.2024
Subjects
Ablation
Cell growth
Cell size
Hypertrophy
Medicin och hälsovetenskap
Skeletal muscle
Transcriptomics
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Summary:Roberts et al. have provided an insightful counterpoint to our review article on the utility of the synergist ablation model. The purpose of this review is to provide some further dialogue regarding the strengths and weaknesses of the synergist ablation model. Specifically, we highlight that the robustness of the model overshadows surgical limitations. We also compare the transcriptomic responses to synergist ablation in mice and resistance exercise in humans to identify common pathways. We conclude that “cell growth is cell growth” and that the mechanisms available to cells to accumulate biomass and increase in size are similar across cell types and independent of the rate of growth.
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ISSN:0363-6143
1522-1563
1522-1563
DOI:10.1152/ajpcell.00418.2024