Synthesis of (+/−)–1′-Aza-carbocyclic-pyrimidine-2′,3′-dideoxynucleoside analogues as potential anti-HIV agents

1′-Aza-carbocyclic-2′, 3′-dideoxyuridine, 3′-deoxythymidine and 2′, 3′-dideoxycytidine were synthesized from 1-aminopyrrolidine intermediate 13 and evaluated as anti-HIV agents in MT-4 cells. 1′-A za-carboxyclic analogues 6–8 were synthesized and evaluated as anti-HIV agents in MT-4 cells....

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 1; no. 12; pp. 757 - 760
Main Authors Mansour, Tarek S., Jin, Haolun
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 1991
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Summary:1′-Aza-carbocyclic-2′, 3′-dideoxyuridine, 3′-deoxythymidine and 2′, 3′-dideoxycytidine were synthesized from 1-aminopyrrolidine intermediate 13 and evaluated as anti-HIV agents in MT-4 cells. 1′-A za-carboxyclic analogues 6–8 were synthesized and evaluated as anti-HIV agents in MT-4 cells.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)81063-5