AMELIORATIVE EFFECT OF HIBISCUS SABDARIFFA LINN ON SUBCHRONIC CHLORPYRIFOS-INDUCED ALTERATIONS IN SEX AND THYROID HORMONES IN MALE WISTAR RATS

• Published in: American journal of pharmacology and toxicology Vol. 9; no. 1; pp. 96 - 106
• Main Authors: Muftau, Shittu, Aisha, Olatunji Omobolanle, Ambali, Suleiman Folorunsho, Oyedepo, Ibrahim Tunde, Umaru, Kawu Muhammed, Yusuf, Peter Ofemile, Ishaku, Kobo Patricia, Isa, Hamza Ibrahim
• Format: Journal Article
• Language: English
• Published: 01.01.2014
• Subjects: Hibiscus
• ISSN: 1557-4962; 1557-4970
• DOI: 10.3844/ajptsp.2014.96.106

Studies have shown that Chlorpyrifos (CPF), an Organophosphate (OP) insecticide alters both sex and thyroid hormones. Apart from inhibiting Acetylcholinesterase activity, CPF has been shown to cause oxidative stress. The antioxidant potentials of many flavonoid-containing plants are increasingly being exploited in the therapy of many infectious and non-infectious diseases. Hibiscus Sabdariffa (HS) is one of the most widely used nutraceuticals that has been used traditionally to combat various illnesses due to its high flavonoid contents. The present study was therefore aimed at evaluating the ameliorative potentials of HS on subchronic chlorpyrifos-evoked alterations in sex and thyroid hormones in male Wistar rats. It is therefore concluded that pretreatment of individuals who are occupationally exposed to CPF and probably other OPs with the extract of HS may result in protection from the insecticide-induced adverse reproductive health outcomes.