Urgent endovascular repair of juxtarenal/pararenal aneurysm by off-the-shelf multibranched endograft

• Published in: Journal of vascular surgery Vol. 80; no. 5; pp. 1336 - 1349.e4
• Main Authors: Gallitto, Enrico, Faggioli, Gianluca, Austermann, Martin, Kölbel, Tilo, Tsilimparis, Nikolas, Dias, Nuno, Melissano, Germano, Simonte, Gioele, Katsargyris, Athanasios, Oikonomou, Kyriakos, Mani, Kevin, Pedro, Luis Mendes, Cecere, Fabrizio, Haulon, Stephan, Gargiulo, Mauro, Antonello, M., Arzola, H., Austerman, M., Berekoven, B., Bertoglio, L., Bonardelli, S., Bonvini, S., Cappiello, A., Cecere, F., Chiesa, R., Dias, N., Di Marzo, L., D'Oria, M., Faggioli, G., Ferrer, C., Fontaine, V., Freyrie, A., Gallitto, E., Gargiulo, M., Giudice, R., Haulon, S., Isernia, G., Leone, N., Lepidi, S., Mani, K., Mansour, W., Melissano, G., Melloni, A., Melo, R., Mendes Pedro, L., Mezzetto, L., Mitta, N., Nana, P., Oikonou, K., Panuccio, G., Perini, P., Pini, R., Pratesi, G., Pulli, R., Piazza, M., Kahlberg, A., Karelis, A., Katsargyris, A., Kolbel, T., Silingardi, R., Simonte, G., Spath, P., Squizzato, F., Tinelli, G., Torrealba, J., Tsilimparis, N., Wanhainen, A., Vacirca, A., Veraldi, G.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.11.2024
• Subjects: Branched endograft; Juxta/Pararenal aneurysm; Off the shelf endograft; Thoracoabdominal; Urgent endovascular repair; Juxta/Pararenal aneurysm; Branched endograft; Off the shelf endograft; Thoracoabdominal; Urgent endovascular repair
• ISSN: 0741-5214; 1097-6809; 1097-6809
• DOI: 10.1016/j.jvs.2024.07.005

To report outcomes of urgent juxtarenal/pararenal aneurysms (J/P-AAAs) managed by off-the-shelf multibranched thoracoabdominal endografts (Cook, T-branch). In this observational, multicenter, retrospective study, patients with J/P-AAAs treated by urgent endovascular repair by T-branch in 23 European aortic centers, from 2013 to 2023, were analyzed. Contained J/P-AAAs rupture, presence of related symptoms, and aneurysm diameter of >70 mm were considered as indication for urgent repair. Technical success (TS), spinal cord ischemia (SCI), and 30-day/hospital mortality were assessed as early outcomes. Survival, freedom from reinterventions, and target artery instability (TAI) were evaluated during follow-up. Overall, 197 patients (J-AAAs, n = 64 [33%]; P-AAAs, n = 95 [48%]; previous failed endovascular aneurysm repair (EVAR), n = 38 [19%]) were analyzed. The mean age and aneurysm diameter was 75 ± 8 years and 76 ± 4 mm, respectively. The American Society of Anesthesiologists score was 3 and 4 in 118 (60%) and 79 (40%) patients. Rupture, symptoms, and diameter of >70 mm were present in 51 (26%), 110 (56%), and 53 (27%) patients, respectively. An adjunctive proximal thoracic endograft was used in 28 cases (14%). The mean aortic coverage between the upper portion of the endograft and the lowest renal artery was 154 ± 49 mm. Single-stage repair and cerebrospinal fluid drainage were reported in 144 (73%) and 53 (27%) cases, respectively. TS was achieved in 182 (92%) cases (rupture, 84% vs no rupture, 95%; P = .02). Failures consist of TA loss (11 [6%]: renal artery, 9; celiac trunk, 2), type I to III endoleaks (2 [1%]), and 24-h mortality (2 [1%]). Rupture was a risk factor for technical failure (P = .02; odds ratio [OR], 3.8; 95% confidence interval [CI], 1.1-12.1). Overall, 15 patients (8%) had persistent SCI (rupture, 14% vs no rupture, 5%) with 11 (6%) , of paraplegia (rupture, 10% vs no rupture, 5%; P = .001). Rupture (P = .04; OR, 3.1; 95% CI, 1.1-8.9) and adjunctive proximal thoracic endograft (P = .01; OR, 4.1; 95% CI, 1.3-12.9) were risk-factors for SCI. Twenty-two patients (11%) died within 30 days or during a prolonged hospitalization. Previous failed EVAR (P = .04; OR, 3.6; 95% CI, 1.1-12.3), paraplegia (P < .001; OR, 9.9; 95% CI, 1.6-62.2) and postoperative mesenteric complications (P = .03; OR, 10.4; 95% CI, 1.2-93.3), as well as cardiac (P = .03; OR, 8.2; 95% CI, 2.0-33.0) and respiratory (P < .001; OR, 10.1; 95% CI, 2.9-35.2) morbidities were associated with 30-day/hospital mortality. The mean follow-up was 19 ± 5 months. The estimated 3-year survival and freedom from reinterventions was 58% and 77%, respectively. TAI occurred in 27 patients (14%) (occlusion, 15; endoleak, 14) with an estimated 3-year freedom from TAI of 72%. Urgent repair of J/P-AAAs by T-branch is feasible and effective with satisfactory TS and 30-day/hospital mortality in high-risk patients. However, extensive aortic coverage is necessary, leading to a non-negligible SCI rate, especially in case of aortic rupture or when adjunctive thoracic endografts are necessary. Previous failed EVAR and postoperative mesenteric complications, as well as cardiac and respiratory morbidities were associated with 30-day/hospital mortality and should be subjected to more research for the purposes of improving outcomes.