Adverse allergic reaction to 131I MIBG

• Published in: Annals of nuclear medicine Vol. 23; no. 7; pp. 697 - 699
• Main Authors: Ishibashi, Naoya, Abe, Katsumi, Furuhashi, Satoru, Fukushima, Shoko, Yoshinobu, Takashi, Takahashi, Motoichiro, Matsumoto, Chiyuki, Fukuda, Kyoko, Kobayashi, Takayuki, Mochizuki, Norisuke
• Format: Journal Article
• Language: English
• Published: Japan Springer Japan 01.09.2009; Springer Nature B.V
• Subjects: 3-Iodobenzylguanidine - administration & dosage; 3-Iodobenzylguanidine - adverse effects; Adult; Case Report; Humans; Hypersensitivity - etiology; Imaging; Male; Medicine; Medicine & Public Health; Nuclear Medicine; Radiology; Skin Diseases - etiology; Skin Diseases - pathology; I MIBG; Adverse reactions; Radiopharmaceuticals; Skin eruption; Side effect
• ISSN: 0914-7187; 1864-6433
• DOI: 10.1007/s12149-009-0282-0

No adverse allergic reactions to iodine-131-metaiodobenzylguanidine ( 131 I MIBG) at a diagnostic dose have been reported in the English literature. This report of a skin eruption in a 35-year-old man after an intravenous injection of 131 I MIBG strongly suggests an adverse allergic reaction, and is the first to address such a side effect of 131 I MIBG at a diagnostic dose. Erythematous maculopapular eruptions, some of which were contiguous, were seen in a symmetric disposition on the patient’s chest walls, elbows, neck and face 18 h after the 131 I MIBG injection. Antiallergic treatment resolved the lesions completely. There were no possible causes of the exanthema other than the 131 I MIBG injection. Urticaria related to the 131 I MIBG injection and caused by type I allergic reaction was suspected, and these findings point to the possible risk of a hitherto unreported allergic skin reaction to 131 I MIBG. We would like to draw the attention of nuclear physicians to this possible drawback of 131 I MIBG.