Evidence of Association between MTRR and TNF-α Gene Polymorphisms and Oral Health-Related Quality of Life in Children with Anterior Open Bite

• Published in: The Journal of clinical pediatric dentistry Vol. 46; no. 3; pp. 249 - 258
• Main Authors: Teixeira, Ellen Cardoso, das Neves, Bruno Moreira, Castilho, Thuanny, Silva Ramos, Thayane, Flaviana, Adriele, Carelli, Julia, Kuchler, Erika Calvano, Germano, Fabiana Nunes, Alves Antunes, Lívia Azeredo, Antunes, Leonardo Santos
• Format: Journal Article
• Language: English
• Published: Birmingham Journal of Clinical Pediatric Dentistry 01.05.2022
• Subjects: Biomarkers; Caregivers; Children & youth; Cross-sectional studies; Dental occlusion; Dentistry; Families & family life; Genes; Informed consent; Oral hygiene; Parents & parenting; Pediatrics; Quality of life; Questionnaires; Science; Tumor necrosis factor-TNF
• ISSN: 1053-4628; 1557-5268
• DOI: 10.17796/1053-4625-46.3.12

Genetic polymorphisms could explain the inter-individual differences in the oral health-related quality of life (OHRQoL) of children with anterior open bite (AOB). Objective: To assess the impact of AOB on OHRQoL in children and to evaluate whether MTR (rs1805087), MTRR (rs1801394), TGFβ1 (rs1800469) and TNF-α (rs1799964, rs1799724 and rs1800629) genes are potential biomarkers for OHRQoL in children with AOB. Study design: A cross-sectional study was performed with 173 children aged between 2–6 years. The Brazilian version of Early Childhood Oral Health Impact Scale (ECOHIS) was applied. Genetic polymorphisms were analyzed using real-time PCR. Mann-Whitney U-test and Chi-square were used. Results: The overall mean ECOHIS scores were 5.49 (SD= 5.72) and 3.45 (SD = 4.49) (p < 0.01) in the AOB and control groups, respectively. Children with the CC genotype of TNF-α (rs1799724) had a significantly higher psychological QoL level. The MTRR AA genotype group showed a lower QoL level in the child subscale (p = 0.006), function (p = 0.017), and psychological (p = 0.006) domains. There was no significant difference between OHRQoL and the genetic polymorphisms in MTR and TGFβ1. Conclusions: Genetic polymorphisms in TNF-α and MTRR are associated with the impact on the OHRQoL in children with AOB.